Economic Features of Antibiotic Resistance: The Case of Methicillin-Resistant Staphylococcus aureus

Autor: Antoñanzas Villar, Fernando JesúsLozano Fernández, CarmenTorres Manrique, Carmen

Tipo de documento: Artículo de revista

Revista: PharmacoEconomics. ISSN: 1170-7690. Año: 2015. Número: 4. Volumen: 33. Páginas: 285-325.

JCR (datos correspondientes al año 2014):
Social Sciences  Área: ECONOMICS  Quartil: Q1  Lugar área: 33/333  F. impacto: 2,450 
Social Sciences  Área: HEALTH POLICY & SERVICES  Quartil: Q1  Lugar área: 14/71  F. impacto: 2,450 
Science  Área: HEALTH CARE SCIENCES & SERVICES  Quartil: Q2  Lugar área: 33/333  F. impacto: 2,450 
Science  Área: PHARMACOLOGY & PHARMACY  Quartil: Q2  Lugar área: 33/333  F. impacto: 2,450 

SCIMAGO (datos correspondientes al año 2014):
1,014  SNIP: 1,086 




  • Goldsack, J.C., DeRitter, C., Power, M., Clinical, patient experience and cost impacts of performing active surveillance on known methicillin-resistant Staphylococcus aureus positive patients admitted to medical–surgical units (2014) Am J Infect Control, 42, pp. 1039-1043. , PID: 25278390
  • Nulens, E., Broex, E., Ament, A., Cost of the meticillin-resistant Staphylococcus aureus search and destroy policy in a Dutch university hospital (2008) J Hosp Infect, 68, pp. 301-307. , COI: 1:STN:280:DC%2BD1c3jt1CktA%3D%3D, PID: 18353496
  • Köck, R., Becker, K., Cookson, B., Methicillin-resistant Staphylococcus aureus (MRSA): burden of disease and control challenges in Europe (2010) Euro Surveill, 15, p. 19688. , PID: 20961515
  • Gould, I.M., Costs of hospital-acquired methicillin-resistant Staphylococcus aureus (MRSA) and its control (2006) Int J Antimicrob Agents, 28, pp. 379-384. , COI: 1:CAS:528:DC%2BD28XhtFentrjF, PID: 17045462
  • Gould, I.M., Reilly, J., Bunyan, D., Costs of healthcare-associated methicillin-resistant Staphylococcus aureus and its control (2010) Clin Microbiol Infect, 16, pp. 1721-1728. , COI: 1:STN:280:DC%2BC3cbmslahsw%3D%3D, PID: 20825434
  • Shorr, A.F., Epidemiology and economic impact of meticillin-resistant Staphylococcus aureus: review and analysis of the literature (2007) Pharmacoeconomics, 25, pp. 751-768. , PID: 17803334
  • Chen, A.F., Wessel, C.B., Rao, N., Staphylococcus aureus screening and decolonization in orthopaedic surgery and reduction of surgical site infections (2013) Clin Orthop Relat Res, 471, pp. 2383-2399. , PID: 23463284
  • Farbman, L., Avni, T., Rubinovitch, B., Cost–benefit of infection control interventions targeting methicillin-resistant Staphylococcus aureus in hospitals: systematic review (2013) Clin Microbiol Infect, 19, pp. 582-593. , COI: 1:STN:280:DC%2BC3sbktVKrug%3D%3D, PID: 23991635
  • Korczak, D., Schöffmann, C., Medical and health economic evaluation of prevention- and control measures related to MRSA infections or -colonisations at hospitals (2010) GMS Health Technol Assess, 6, p. 04. , PID: 21289877
  • McGinigle, K.L., Gourlay, M.L., Buchanan, I.B., The use of active surveillance cultures in adult intensive care units to reduce methicillin-resistant Staphylococcus aureus-related morbidity, mortality, and costs: a systematic review (2008) Clin Infect Dis, 46, pp. 1717-1725. , PID: 18494098
  • Brown, J., Paladino, J.A., Impact of rapid methicillin-resistant Staphylococcus aureus polymerase chain reaction testing on mortality and cost effectiveness in hospitalized patients with bacteraemia: a decision model (2010) Pharmacoeconomics, 28, pp. 567-575. , PID: 20550222
  • Ager, S., Gould, K., Clinical update on linezolid in the treatment of Gram-positive bacterial infections (2012) Infect Drug Resist, 5, pp. 87-102. , COI: 1:CAS:528:DC%2BC38XhtVakurzE, PID: 22787406
  • Gurasamy, K.S., Koti, R., Toon, C.D., Antibiotic therapy for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) in non surgical wounds (2013) Cochrane Database Syst Rev, 11
  • Watkins, R.R., Lemonovich, T.L., File, T.M., Jr., An evidence-based review of linezolid for the treatment of methicillin-resistant Staphylococcus aureus (MRSA): place in therapy (2012) Core Evid, 7, pp. 131-143. , COI: 1:CAS:528:DC%2BC3sXpsFCktg%3D%3D, PID: 23271985
  • Yue, J., Dong, B.R., Yang, M., Linezolid versus vancomycin for skin and soft tissue infections (2013) Cochrane Database Syst Rev, 7. , PID: 23846850
  • (2009) The bacterial challenge: time to react, ,
  • (2013) Antibiotic resistance threats in the United States, ,
  • Summary of the latest data on antibiotic resistance in the European Union (2013) In:, ,
  • García-Álvarez, L., Holden, M.T., Lindsay, H., Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study (2011) Lancet Infect Dis, 11, pp. 595-603. , PID: 21641281
  • Gómez, P., González-Barrio, D., Benito, D., Detection of methicillin-resistant Staphylococcus aureus (MRSA) carrying the mecC gene in wild small mammals in Spain (2014) J Antimicrob Chemother, 2014 (69), pp. 2061-2064
  • Gu, B., Kelesidis, T., Tsiodras, S., The emerging problem of linezolid-resistant Staphylococcus (2013) J Antimicrob Chemother, 68, pp. 4-11. , COI: 1:CAS:528:DC%2BC38XhvVChsbbN, PID: 22949625
  • Hayden, M.K., Rezai, K., Hayes, R.A., Development of daptomycin resistance in vivo in methicillin-resistant Staphylococcus aureus (2005) J Clin Microbiol, 43, pp. 5285-5287. , COI: 1:CAS:528:DC%2BD2MXhtFGqt7%2FF, PID: 16207998
  • Lozano, C., Gómez-Sanz, E., Benito, D., Staphylococcus aureus nasal carriage, virulence traits, antibiotic resistance mechanisms, and genetic lineages in healthy humans in Spain, with detection of CC398 and CC97 strains (2011) Int J Med Microbiol, 301, pp. 500-505. , COI: 1:CAS:528:DC%2BC3MXoslWgsLw%3D, PID: 21570348
  • Wertheim, H.F., Vos, M.C., Ott, A., Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers (2004) Lancet, 364, pp. 703-705. , PID: 15325835
  • Simor, A.E., Loeb M
  • CIDS/CAMM Guidelines Committee. The management of infection and colonization due to methicillin-resistant Staphylococcus aureus: a CIDS/CAMM position paper (2004) Can J Infect Dis, 15, pp. 39-48. , PID: 18159442
  • Tenover, F.C., Goering, R.V., Methicillin-resistant Staphylococcus aureus strain USA300: origin and epidemiology (2009) J Antimicrob Chemother, 64, pp. 44-46
  • Cercenado, E., Cuevas, O., Marín, M., Community-acquired methicillin-resistant Staphylococcus aureus in Madrid, Spain: transcontinental importation and polyclonal emergence of Panton–Valentine leukocidin positive isolates (2008) Diagn Microbiol Infect Dis, 61, pp. 143-149. , COI: 1:CAS:528:DC%2BD1cXmtVSmsL4%3D, PID: 18280081
  • Gómez-Sanz, E., Torres, C., Lozano, C., Detection, molecular characterization, and clonal diversity of methicillin-resistant Staphylococcus aureus CC398 and CC97 in Spanish slaughter pigs of different age groups (2010) Foodborne Pathog Dis, 7, pp. 1269-1277. , PID: 20677918
  • Khanna, T., Friendship, R., Dewey, C., Methicillin resistant Staphylococcus aureus colonization in pigs and pig farmers (2008) Vet Microbiol, 128, pp. 298-303. , COI: 1:CAS:528:DC%2BD1cXislWhu74%3D, PID: 18023542
  • Lozano, C., Aspiroz, C., Ezpeleta, A.I., Empyema caused by MRSA ST398 with atypical resistance profile, Spain (2011) Emerg Infect Dis, 17, pp. 138-140. , PID: 21192880
  • Lozano, C., Rezusta, A., Gómez, P., High prevalence of spa types associated with the clonal lineage CC398 among tetracycline-resistant methicillin-resistant Staphylococcus aureus strains in a Spanish hospital (2012) J Antimicrob Chemother, 67, pp. 330-334. , COI: 1:CAS:528:DC%2BC38XoslShuw%3D%3D, PID: 22127589
  • (2008) Euro Surveill, , Wulf MW, Markestein A, van der Linden FT, et al. First outbreak of methicillin-resistant Staphylococcus aureus ST398 in a Dutch hospital, June 2007. Feb 28
  • 13(9). pii: 8051
  • Assessment of the public health significance of meticillin resistant Staphylococcus aureus (MRSA) in animals and foods (2009) EFSA J, 993, pp. 1-73
  • Abramson, M.A., Sexton, D.J., Nosocomial methicillin-resistant and methicillin-susceptible Staphylococcus aureus primary bacteremia: at what costs? (1999) Infect Control Hosp Epidemiol, 20, pp. 408-411. , COI: 1:STN:280:DyaK1MzitFSltw%3D%3D, PID: 10395142
  • Anderson, D.J., Kaye, K.S., Chen, L.F., Clinical and financial outcomes due to methicillin resistant Staphylococcus aureus surgical site infection: a multi-center matched outcomes study (2009) PLoS One, 4, p. 8305. , PID: 20016850
  • Ben-David, D., Novikov, I., Mermel, L.A., Are there differences in hospital cost between patients with nosocomial methicillin-resistant Staphylococcus aureus bloodstream infection and those with methicillin-susceptible S. aureus bloodstream infection? (2009) Infect Control Hosp Epidemiol, 30, pp. 453-460. , PID: 19344266
  • Erdem, G., Salazar, R., Kimata, C., Staphylococcus aureus osteomyelitis in Hawaii (2010) Clin Pediatr (Phila), 49, pp. 477-484. , PID: 20118075
  • Filice, G.A., Nyman, J.A., Lexau, C., Lees, C.H., Bockstedt, L.A., Como-Sabetti, K., Lesher, L.J., Lynfield, R., Excess costs and utilization associated with methicillin resistance for patients with Staphylococcus aureus infection (2010) Infect Control Hosp Epidemiol, 31, pp. 365-373. , PID: 20184420
  • Kaye, K.S., Engemann, J.J., Mozaffari, E., Reference group choice and antibiotic resistance outcomes (2004) Emerg Infect Dis, 10, pp. 1125-1128. , PID: 15207068
  • Kopp, B.J., Nix, D.E., Armstrong, E.P., Clinical and economic analysis of methicillin-susceptible and -resistant Staphylococcus aureus infections (2004) Ann Pharmacother, 38, pp. 1377-1382. , PID: 15266044
  • de Kraker, M.E., Wolkewitz, M., Davey, P.G., Clinical impact of antimicrobial resistance in European hospitals: excess mortality and length of hospital stay related to methicillin-resistant Staphylococcus aureus bloodstream infections (2011) Antimicrob Agents Chemother, 55, pp. 1598-1605. , PID: 21220533
  • Lodise, T.P., McKinnon, P.S., Clinical and economic impact of methicillin resistance in patients with Staphylococcus aureus bacteremia (2005) Diagn Microbiol Infect Dis, 52, pp. 113-122. , PID: 15964499
  • Rubio-Terrés, C., Garau, J., Grau, S., Cost of bacteraemia caused by methicillin-resistant vs methicillin-susceptible Staphylococcus aureus in Spain: a retrospective cohort study (2010) Clin Microbiol Infect, 16, pp. 722-728. , PID: 19712112
  • Shorr, A.F., Tabak, Y.P., Gupta, V., Morbidity and cost burden of methicillin-resistant Staphylococcus aureus in early onset ventilator-associated pneumonia (2006) Crit Care, 10, p. 97. , PID: 16808853
  • Gómez-Pavón, J., RodríguezSalazar, J., de la Fernández Puente, E., Staphylococcus aureus infection in an acute geriatric unit (2010) Rev Esp Geriatr Gerontol, 45, pp. 5-9. , PID: 20044174
  • Athanasakis, K., Petrakis, I., Ollandezos, M., Antibacterial treatment of meticillin-resistant Staphylococcus aureus complicated skin and soft tissue infections: a cost and budget impact analysis in Greek hospitals. Infect Dis Ther (2014) Epub, p. 7
  • Angelis, G., Allignol, A., Murthy, A., Multistate modelling to estimate the excess length of stay associated with meticillin-resistant Staphylococcus aureus colonisation and infection in surgical patients (2011) J Hosp Infect, 78, pp. 86-91. , PID: 21481492
  • Goetghebeur, M., Landry, P.A., Han, D., Methicillin-resistant Staphylococcus aureus: a public health issue with economic consequences (2007) Can J Infect Dis Med Microbiol, 18, pp. 27-34. , PID: 18923684
  • Hübner, C., Hübner, N.O., Hopert, K., Analysis of MRSA-attributed costs of hospitalized patients in Germany (2014) Eur J Clin Microbiol Infect Dis, 33, pp. 1817-1822. , PID: 24838677
  • Kanerva, M., Blom, M., Tuominen, U., Costs of an outbreak of meticillin-resistant Staphylococcus aureus (2007) J Hosp Infect, 66, pp. 22-28. , COI: 1:STN:280:DC%2BD2s3ntF2mtg%3D%3D, PID: 17433492
  • Kim, T., Oh, P.I., Simor, A.E., The economic impact of methicillin-resistant Staphylococcus aureus in Canadian hospitals (2001) Infect Control Hosp Epidemiol, 22, pp. 99-104. , COI: 1:STN:280:DC%2BD3M3gsVektA%3D%3D, PID: 11232886
  • de Kraker, M.E., Davey, P.G., Grundmann, H., Mortality and hospital stay associated with resistant Staphylococcus aureus and Escherichia coli bacteremia: estimating the burden of antibiotic resistance in Europe (2011) PLoS Med, 8, p. 1001104. , PID: 22022233
  • Labreche, M.J., Lee, G.C., Attridge, R.T., Treatment failure and costs in patients with methicillin-resistant Staphylococcus aureus (MRSA) skin and soft tissue infections: a South Texas Ambulatory Research Network (STARNet) study (2013) J Am Board Fam Med, 26, pp. 508-517. , PID: 24004702
  • Lee, B.Y., Singh, A., David, M.Z., The economic burden of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) (2013) Clin Microbiol Infect, 19, pp. 528-536. , COI: 1:STN:280:DC%2BC38jjtVKrtQ%3D%3D, PID: 22712729
  • Macedo-Viñas, M., De Angelis, G., Rohner, P., Burden of meticillin-resistant Staphylococcus aureus infections at a Swiss university hospital: excess length of stay and costs (2013) J Hosp Infect, 84, pp. 132-137. , PID: 23608003
  • Ramanathan, V., Chiu, E.J., Thomas, J.T., Khan, A., Dolson, G.M., Darouiche, R.O., Healthcare costs associated with hemodialysis catheter-related infections: a single-center experience (2007) Infect Control Hosp Epidemiol, 28, pp. 606-609. , PID: 17464925
  • Resch, A., Wilke, M., Fink, C., The cost of resistance: incremental cost of methicillin-resistant Staphylococcus aureus (MRSA) in German hospitals (2009) Eur J Health Econ, 10, pp. 287-297. , PID: 19015905
  • Schultz, E.D., Tanaka, D.T., Goldberg, R.N., Effect of methicillin-resistant Staphylococcus aureus colonization in the neonatal intensive care unit on total hospital cost (2009) Infect Control Hosp Epidemiol, 30, pp. 383-385. , PID: 19222371
  • Smith, R.D., Yago, M., Millar, M., A macroeconomic approach to evaluating policies to contain antimicrobial resistance: a case study of methicillin-resistant Staphylococcus aureus (MRSA) (2006) Appl Health Econ Health Policy, 5, pp. 55-65. , PID: 16774293
  • Watters, K., O’Dwyer, T.P., Rowley, H., Cost and morbidity of MRSA in head and neck cancer patients: what are the consequences? (2004) J Laryngol Otol, 118, pp. 694-699. , COI: 1:STN:280:DC%2BD2crjvVKltw%3D%3D, PID: 15509366
  • Weigelt, J.A., Lipsky, B.A., Tabak, Y.P., Surgical site infections: causative pathogens and associated outcomes (2010) Am J Infect Control, 38, pp. 112-120. , PID: 19889474
  • Clancy, C.J., Bartsch, S.M., Nguyen, M.H., A computer simulation model of the cost-effectiveness of routine Staphylococcus aureus screening and decolonization among lung and heart–lung transplant recipients (2014) Eur J Clin Microbiol Infect Dis, 33, pp. 1053-1061. , COI: 1:STN:280:DC%2BC2cvisVKguw%3D%3D, PID: 24500598
  • Courville, X.F., Tomek, I.M., Kirkland, K.B., Cost-effectiveness of preoperative nasal mupirocin treatment in preventing surgical site infection in patients undergoing total hip and knee arthroplasty: a cost-effectiveness analysis (2012) Infect Control Hosp Epidemiol, 33, pp. 152-159. , PID: 22227984
  • Diller, R., Sonntag, A.K., Mellmann, A., Evidence for cost reduction based on pre-admission MRSA screening in general surgery (2008) Int J Hyg Environ Health, 211, pp. 205-212. , PID: 17692566
  • Elliott, R.A., Weatherly, H.L., Hawkins, N.S., An economic model for the prevention of MRSA infections after surgery: non-glycopeptide or glycopeptides antibiotic prophylaxis? (2010) Eur J Health Econ, 11, pp. 57-66. , PID: 19669182
  • Gurieva, T., Bootsma, M.C., Bonten, M.J., Cost and effects of different admission screening strategies to control the spread of methicillin-resistant Staphylococcus aureus (2013) PLoS Comput Biol, 9, p. 1002874. , COI: 1:CAS:528:DC%2BC3sXkt1Wms7g%3D, PID: 23436984
  • Huang, S.S., Septimus, E., Avery, T.R., Cost savings of universal decolonization to prevent intensive care unit infection: implications of the reduce MRSA trial (2014) Infect Control Hosp Epidemiol, 35, pp. 23-31. , PID: 25222894
  • Lee, B.Y., Tsui, B.Y., Bailey, R.R., Should vascular surgery patients be screened preoperatively for methicillin-resistant Staphylococcus aureus? (2009) Infect Control Hosp Epidemiol, 30, pp. 1158-1165. , PID: 19852665
  • Lee, B.Y., Wiringa, A.E., Bailey, R.R., Screening cardiac surgery patients for MRSA: an economic computer model (2010) Am J Manag Care, 16, pp. 163-173. , PID: 20645662
  • Lee, B.Y., Wiringa, A.E., Bailey, R.R., The economic effect of screening orthopedic surgery patients preoperatively for methicillin-resistant Staphylococcus aureus (2010) Infect Control Hosp Epidemiol, 31, pp. 1130-1138. , PID: 20923285
  • Lee, B.Y., Song, Y., McGlone, S.M., The economic value of screening haemodialysis patients for methicillin-resistant Staphylococcus aureus in the USA (2011) Clin Microbiol Infect, 17, pp. 1717-1726. , COI: 1:STN:280:DC%2BC3Mbps1ygug%3D%3D, PID: 21595796
  • Mueller, S.W., Krebsbach, L.E., Impact of an antimicrobial-impregnated gauze dressing on surgical site infections including methicillin-resistant Staphylococcus aureus infections (2008) Am J Infect Control, 36, pp. 651-655. , PID: 18834734
  • Nelson, R.E., Samore, M.H., Smith, K.J., Cost-effectiveness of adding decolonization to a surveillance strategy of screening and isolation for methicillin-resistant Staphylococcus aureus carriers (2010) Clin Microbiol Infect, 16, pp. 1740-1746. , COI: 1:STN:280:DC%2BC3cbms1ygsA%3D%3D, PID: 20673265
  • Noskin, G.A., Rubin, R.J., Schentag, J.J., Budget impact analysis of rapid screening for Staphylococcus aureus colonization among patients undergoing elective surgery in US hospitals (2008) Infect Control Hosp Epidemiol, 29, pp. 16-24. , PID: 18171182
  • Olchanski, N., Mathews, C., Fusfeld, L., Assessment of the influence of test characteristics on the clinical and cost impacts of methicillin-resistant Staphylococcus aureus screening programs in US hospitals (2011) Infect Control Hosp Epidemiol, 32, pp. 250-257. , PID: 21460510
  • Petlin, A., Schallom, M., Prentice, D., Chlorhexidine gluconate bathing to reduce methicillin-resistant Staphylococcus aureus acquisition (2014) Crit Care Nurse, 34, pp. 17-24. , PID: 25274761
  • Robotham, J.V., Graves, N., Cookson, B.D., Screening, isolation, and decolonisation strategies in the control of meticillin resistant Staphylococcus aureus in intensive care units: cost effectiveness evaluation (2011) BMJ, 343, p. 5694. , PID: 21980062
  • Wassenberg, M.W., de Wit, G.A., Bonten, M.J., Cost-effectiveness of preoperative screening and eradication of Staphylococcus aureus carriage (2011) PLoS One, 6, p. 14815. , COI: 1:CAS:528:DC%2BC3MXntVajt78%3D, PID: 21637333
  • You, J.H., Chan, C.Y., Wong, M.Y., Active surveillance and decolonization of methicillin-resistant Staphylococcus aureus on admission to neonatal intensive care units in Hong Kong: a cost-effectiveness analysis (2012) Infect Control Hosp Epidemiol, 33, pp. 1024-1030. , PID: 22961022
  • van Hal, S.J., Stark, D., Lockwood, B., Methicillin-resistant Staphylococcus aureus (MRSA) detection: comparison of two molecular methods (IDI-MRSAPCR assay and GenoType MRSA Direct PCR assay) with three selective MRSA agars (MRSA ID, MRSASelect, andCHROMagar MRSA) for use with infection-control swabs (2007) J Clin Microbiol, 45, pp. 2486-2490. , PID: 17537949
  • Henson, G., Ghonim, E., Swiatlo, A., Cost–benefit and effectiveness analysis of rapid testing for MRSA carriage in a hospital setting (2014) Clin Lab Sci, 27, pp. 13-20. , PID: 24669442
  • Shrestha, N.K., Shermock, K.M., Gordon, S.M., Predictive value and cost-effectiveness analysis of a rapid polymerase chain reaction for preoperative detection of nasal carriage of Staphylococcus aureus (2003) Infect Control Hosp Epidemiol, 24, pp. 327-333. , PID: 12785405
  • Yossepowitch, O., Dan, M., Kutchinsky, A., A cost-saving algorithm for rapid diagnosis of Staphylococcus aureus and susceptibility to oxacillin directly from positive blood culture bottles by combined testing with BinaxNOW® S. aureus and Xpert MRSA/SA Assay (2014) Diagn Microbiol Infect Dis, 78, pp. 352-355. , COI: 1:CAS:528:DC%2BC2cXhvVajtbg%3D, PID: 24503507
  • Lodise, T.P., Graves, J., Evans, A., Relationship between vancomycin MIC and failure among patients with methicillin-resistant Staphylococcus aureus bacteremia treated with vancomycin (2008) Antimicrob Agents Chemother, 52, pp. 3315-3320. , COI: 1:CAS:528:DC%2BD1cXhtF2gt77I, PID: 18591266
  • Soriano, A., Marco, F., Martínez, J.A., Influence of vancomycin minimum inhibitory concentration on the treatment of methicillin-resistant Staphylococcus aureus bacteremia (2008) Clin Infect Dis, 46, pp. 193-200. , COI: 1:CAS:528:DC%2BD1cXhvVClsbk%3D, PID: 18171250
  • Hope, R., Blackburn, R.M., Verlander, N.Q., Vancomycin MIC as a predictor of outcome in MRSA bacteraemia in the UK context (2013) J Antimicrob Chemother, 68, pp. 2641-2647. , COI: 1:CAS:528:DC%2BC3sXhs1Cmur%2FP, PID: 23794604
  • Rojas, L., Bunsow, E., Muñoz, P., Vancomycin MICs do not predict the outcome of methicillin-resistant Staphylococcus aureus bloodstream infections in correctly treated patients (2012) J Antimicrob Chemother, 67, pp. 1760-1768. , COI: 1:CAS:528:DC%2BC38Xotleqsr0%3D, PID: 22556382
  • Walraven, C.J., North, M.S., Marr-Lyon, L., Site of infection rather than vancomycin MIC predicts vancomycin treatment failure in methicillin-resistant Staphylococcus aureus bacteraemia (2011) J Antimicrob Chemother, 66, pp. 2368-2392
  • Seaton, R.A., Johal, S., Coia, J.E., Economic evaluation of treatment for MRSA complicated skin and soft tissue infections in Glasgow hospitals (2014) Eur J Clin Microbiol Infect Dis, 33, pp. 305-311. , COI: 1:STN:280:DC%2BC3sbktlKjtw%3D%3D, PID: 23995977
  • Stephens, J.M., Gao, X., Patel, D.A., Economic burden of inpatient and outpatient antibiotic treatment for methicillin-resistant Staphylococcus aureus complicated skin and soft-tissue infections: a comparison of linezolid, vancomycin, and daptomycin (2013) Clinicoecon Outcomes Res, 5, pp. 447-457. , PID: 24068869
  • Eckmanna, C., Lawson, W., Nathwani, D., Antibiotic treatment patterns across Europe in patients with complicated skin and soft-tissue infections due to meticillin-resistant Staphylococcus aureus: a plea for implementation of early switch and early discharge criteria (2014) Int J Antimicrob Agents, 44, pp. 56-64
  • (2014) Clin Microbiol Infect, , Nathwani D, Eckmann C, Lawson W, et al. Pan-European early switch/early discharge opportunities exist for hospitalized patients with methicillin-resistant Staphylococcus aureus complicated skin and soft tissue infections
  • Bounthavong, M., Zargarzadeh, A., Hsu, D.I., Cost-effectiveness analysis of linezolid, daptomycin, and vancomycin in methicillin-resistant Staphylococcus aureus: complicated skin and skin structure infection using Bayesian methods for evidence synthesis (2011) Value Health, 14, pp. 631-639. , PID: 21839399
  • Brown, J., Brown, K.A., Forrest, A., Outcomes and costs associated with a history of vancomycin exposure in patients with MRSA-related complicated bacteremia and infective endocarditis (2011) Clin Ther, 33, pp. 1475-1482. , PID: 21925733
  • Campbell, M.L., Marchaim, D., Pogue, J.M., Treatment of methicillin-resistant Staphylococcus aureus infections with a minimal inhibitory concentration of 2 μg/mL to vancomycin: old (trimethoprim/sulfamethoxazole) versus new (daptomycin or linezolid) agents (2012) Ann Pharmacother, 46, pp. 1587-1597. , PID: 23212935
  • De Cock, E., Krueger, W.A., Sorensen, S., Cost-effectiveness of linezolid vs vancomycin in suspected methicillin-resistant Staphylococcus aureus nosocomial pneumonia in Germany (2009) Infection, 37, pp. 123-132. , PID: 19277465
  • Kullar, R., Davis, S.L., Taylor, T.N., Effects of targeting higher vancomycin trough levels on clinical outcomes and costs in a matched patient cohort (2012) Pharmacotherapy, 32, pp. 195-201. , PID: 22392452
  • Kullar, R., Davis, S.L., Kaye, K.S., Implementation of an antimicrobial stewardship pathway with daptomycin for optimal treatment of methicillin-resistant Staphylococcus aureus bacteremia (2013) Pharmacotherapy, 33, pp. 3-10. , COI: 1:CAS:528:DC%2BC3sXjvVOnu7k%3D, PID: 23307539
  • Laohavaleeson, S., Barriere, S.L., Nicolau, D.P., Cost-effectiveness of telavancin versus vancomycin for treatment of complicated skin and skin structure infections (2008) Pharmacotherapy, 28, pp. 1471-1482. , PID: 19025428
  • Lipsky, B.A., Napolitano, L.M., Moran, G.J., Economic outcomes of inappropriate initial antibiotic treatment for complicated skin and soft tissue infections: a multicenter prospective observational study (2014) Diagn Microbiol Infect Dis, 79, pp. 266-272. , COI: 1:STN:280:DC%2BC2crmt1KnsA%3D%3D, PID: 24657171
  • McKinnon, P.S., Sorensen, S.V., Liu, L.Z., Impact of linezolid on economic outcomes and determinants of cost in a clinical trial evaluating patients with MRSA complicated skin and soft-tissue infections (2006) Ann Pharmacother, 40, pp. 1017-1023. , PID: 16720705
  • Miedzybrodzki, R., Fortuna, W., Weber-Dabrowska, B., Phage therapy of staphylococcal infections (including MRSA) may be less expensive than antibiotic treatment (2007) Postepy Hig Med Dosw (Online), 61, pp. 461-465. , PID: 17679835
  • Patel, D.A., Shorr, A.F., Chastre, J., Modeling the economic impact of linezolid versus vancomycin in confirmed nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus (2014) Crit Care, 18, p. 157. , PID: 25053453
  • Sharpe, J.N., Shively, E.H., Polk, H.C., Jr., Clinical and economic outcomes of oral linezolid versus intravenous vancomycin in the treatment of MRSA-complicated, lower-extremity skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus (2005) Am J Surg, 189, pp. 425-428. , PID: 15820454
  • Rosner, A.J., Becker, D.L., Wong, A.H., The costs and consequences of methicillin-resistant Staphylococcus aureus infection treatments in Canada (2004) Can J Infect Dis Med Microbiol, 15, pp. 213-220. , PID: 18159495
  • Rubio-Terrés, C., Rubio-Rodríguez, D., Majos, N., Pharmacoeconomic analysis of the treatment of methicillin-resistant Staphylococcus aureus with daptomycin or vancomycin (2012) Rev Esp Quimioter, 25, pp. 283-292. , PID: 23303261
  • Schürmann, D., Sorensen, S.V., De Cock, E., Cost-effectiveness of linezolid versus vancomycin for hospitalised patients with complicated skin and soft-tissue infections in Germany (2009) Eur J Health Econ, 10, pp. 65-79. , PID: 18437437
  • Wright, B.M., Eiland, E.H., 3rd, Retrospective analysis of clinical and cost outcomes associated with methicillin-resistant Staphylococcus aureus complicated skin and skin structure infections treated with daptomycin, vancomycin, or linezolid (2011) J Pathog, 2011, p. 347969. , PID: 22567330
  • Young, M.J., Hodges, G., McCardle, J.E., Cost avoidance using linezolid for methicillin-resistant Staphylococcus aureus infections in a specialist diabetes foot clinic (2012) J Antimicrob Chemother, 67, pp. 2974-2975. , COI: 1:CAS:528:DC%2BC38Xhs1Glu7jP, PID: 22904240