Correlation Between Serum 25-Hydroxyvitamin D and Virulence Genes of Staphylococcus aureus Isolates Colonizing Children with Atopic Dermatitis

Autor: Gilaberte, Y.; Sanmartin, R.; Aspiroz, C.; Hernandez-Martin, A.; Benito, D.; Sanz-Puertolas, P.; Alonso, M.; Torrelo, A.; Torres Manrique, Carmen

Tipo de documento: Artículo de revista

Revista: Pediatric Dermatology. ISSN: 0736-8046. Año: 2015. Número: 4. Volumen: 32. Páginas: 506-513.

doi 10.1111/pde.12436Texto completo open access 

SCIMAGO (datos correspondientes al año 2014):
,568  SNIP: ,92 



  • Rybojad, M., Atopic dermatitis (2012) Arch Pediatr, 19, pp. 882-885
  • Ong, P.Y., Leung, D.Y., The infectious aspects of atopic dermatitis (2010) Immunol Allergy Clin North Am, 30, pp. 309-321
  • Kong, H.H., Oh, J., Deming, C., Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis (2012) Genome Res, 22, pp. 850-859
  • Suh, L., Coffin, S., Leckerman, K.H., Methicillin-resistant Staphylococcus aureus colonization in children with atopic dermatitis (2008) Pediatr Dermatol, 25, pp. 528-534
  • Ring, J., Abeck, D., Neuber, K., Atopic eczema: Role of microorganisms on the skin surface (1992) Allergy, 47, pp. 265-269
  • Nomura, I., Tanaka, K., Tomita, H., Evaluation of the staphylococcal exotoxins and their specific IgE in childhood atopic dermatitis (1999) J Allergy Clin Immunol, 104, pp. 441-446
  • Youssef, D.A., Miller, C.W., El-Abbassi, A.M., Antimicrobial implications of vitamin D (2011) Dermatoendocrinol, 3, pp. 220-229
  • Searing, D.A., Leung, D.Y., Vitamin D in atopic dermatitis, asthma and allergic diseases (2010) Immunol Allergy Clin North Am, 30, pp. 397-409
  • Hata, T.R., Kotol, P., Jackson, M., Administration of oral vitamin D induces cathelicidin production in atopic individuals (2008) J Allergy Clin Immunol, 122, pp. 829-831
  • Liu, P.T., Stenger, S., Li, H., Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response (2006) Science, 311, pp. 1770-1773
  • De, D., Kanwar, A.J., Handa, S., Comparative efficacy of Hanifin and Rajka's criteria and the UK working party's diagnostic criteria in diagnosis of atopic dermatitis in a hospital setting in North India (2006) J Eur Acad Dermatol Venereol, 20, pp. 853-859
  • Kunz, B., Oranje, A.P., Labreze, L., Clinical validation and guidelines for the SCORAD index: Consensus report of the European Task Force on Atopic Dermatitis (1997) Dermatology, 195, pp. 10-19
  • Halvorsen, R., Jenner, A., Hagelin, E.M., Phadiatop infant in the diagnosis of atopy in children with allergy-like symptoms (2009) Int J Pediatr, 2009, p. 460737
  • Holick, M.F., Vitamin D: A d-lightful solution for health (2011) J Investig Med, 59, pp. 872-880
  • Lozano, C., Gomez-Sanz, E., Benito, D., Staphylococcus aureus nasal carriage, virulence traits, antibiotic resistance mechanisms, and genetic lineages in healthy humans in Spain, with detection of CC398 and CC97 strains (2011) Int J Med Microbiol, 301, pp. 500-505
  • Benito, D., Lozano, C., Gomez-Sanz, E., Detection of methicillin-susceptible Staphylococcus aureus ST398 and ST133 strains in gut microbiota of healthy humans in Spain (2013) Microb Ecol, 66, pp. 105-111
  • Chiu, L.S., Ho, M.S., Hsu, L.Y., Prevalence and molecular characteristics of Staphylococcus aureus isolates colonizing patients with atopic dermatitis and their close contacts in Singapore (2009) Br J Dermatol, 160, pp. 965-971
  • Na, S.Y., Roh, J.Y., Kim, J.M., Analysis of colonization and genotyping of the exotoxins of Staphylococcus aureus in patients with atopic dermatitis (2012) Ann Dermatol, 24, pp. 413-419
  • Breuer, K., Kapp, A., Werfel, T., Bacterial infections and atopic dermatitis (2001) Allergy, 56, pp. 1034-1041
  • Chiu, L.S., Chow, V.C., Ling, J.M., Staphylococcus aureus carriage in the anterior nares of close contacts of patients with atopic dermatitis (2010) Arch Dermatol, 146, pp. 748-752
  • Salgado, C.D., Farr, B.M., Calfee, D.P., Community-acquired methicillin-resistant Staphylococcus aureus: A meta-analysis of prevalence and risk factors (2003) Clin Infect Dis, 36, pp. 131-139
  • Huang, J.T., Abrams, M., Tlougan, B., Treatment of Staphylococcus aureus colonization in atopic dermatitis decreases disease severity (2009) Pediatrics, 123, pp. e808-e814
  • Matiz, C., Tom, W.L., Eichenfield, L.F., Children with atopic dermatitis appear less likely to be infected with community acquired methicillin-resistant Staphylococcus aureus: The San Diego experience (2011) Pediatr Dermatol, 28, pp. 6-11
  • Breuer, K., Wittmann, M., Bosche, B., Severe atopic dermatitis is associated with sensitization to staphylococcal enterotoxin B (SEB) (2000) Allergy, 55, pp. 551-555
  • Leung, D.Y., Harbeck, R., Bina, P., Presence of IgE antibodies to staphylococcal exotoxins on the skin of patients with atopic dermatitis. Evidence for a new group of allergens (1993) J Clin Invest, 92, pp. 1374-1380
  • MacHura, E., Karczewska, K., Findysz-Wylag, B., Influence of Staphylococcus aureus skin colonization on degree of sensitization in atopic dermatitis children (2008) Pol Merkur Lekarski, 25, pp. 51-56
  • Olsen, K., Falch, B.M., Danielsen, K., Staphylococcus aureus nasal carriage is associated with serum 25-hydroxyvitamin D levels, gender and smoking status. The Tromso Staph and Skin Study (2012) Eur J Clin Microbiol Infect Dis, 31, pp. 465-473
  • Williams, J.V., Vowels, B.R., Honig, P.J., S. Aureus isolation from the lesions, the hands, and the anterior nares of patients with atopic dermatitis (1998) Pediatr Dermatol, 15, pp. 194-198
  • Gilani, S.J., Gonzalez, M., Hussain, I., Staphylococcus aureus re-colonization in atopic dermatitis: Beyond the skin (2005) Clin Exp Dermatol, 30, pp. 10-13
  • Hon, K.L., Lam, M.C., Leung, T.F., Clinical features associated with nasal Staphylococcus aureus colonisation in Chinese children with moderate-to-severe atopic dermatitis (2005) Ann Acad Med Singapore, 34, pp. 602-605
  • Pascolini, C., Sinagra, J., Pecetta, S., Molecular and immunological characterization of Staphylococcus aureus in pediatric atopic dermatitis: Implications for prophylaxis and clinical management (2011) Clin Dev Immunol, 2011, p. 718708
  • Kim, D.W., Park, J.Y., Park, K.D., Are there predominant strains and toxins of Staphylococcus aureus in atopic dermatitis patients? Genotypic characterization and toxin determination of S. Aureus isolated in adolescent and adult patients with atopic dermatitis (2009) J Dermatol, 36, pp. 75-81
  • Rosen, C.J., Abrams, S.A., Aloia, J.F., IOM committee members respond to Endocrine Society vitamin D guideline (2012) J Clin Endocrinol Metab, 97, pp. 1146-1152
  • Holick, M.F., Binkley, N.C., Bischoff-Ferrari, H.A., Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline (2011) J Clin Endocrinol Metab, 96, pp. 1911-1930
  • Powe, C.E., Evans, M.K., Wenger, J., Vitamin D-binding protein and vitamin D status of black Americans and white Americans (2013) N Engl J Med, 369, pp. 1991-2000
  • Peroni, D.G., Piacentini, G.L., Cametti, E., Correlation between serum 25-hydroxyvitamin D levels and severity of atopic dermatitis in children (2011) Br J Dermatol, 164, pp. 1078-1082
  • Amestejani, M., Salehi, B.S., Vasigh, M., Vitamin D supplementation in the treatment of atopic dermatitis: A clinical trial study (2012) J Drugs Dermatol, 11, pp. 327-330
  • Sidbury, R., Sullivan, A.F., Thadhani, R.I., Randomized controlled trial of vitamin D supplementation for winter-related atopic dermatitis in Boston: A pilot study (2008) Br J Dermatol, 159, pp. 245-247
  • Chiu, Y.E., Havens, P.L., Siegel, D.H., Serum 25-hydroxyvitamin D concentration does not correlate with atopic dermatitis severity (2013) J Am Acad Dermatol, 69, pp. 40-46
  • Akan, A., Azkur, D., Ginis, T., Vitamin D level in children is correlated with severity of atopic dermatitis but only in patients with allergic sensitizations (2013) Pediatr Dermatol, 30, pp. 359-363
  • Samochocki, Z., Bogaczewicz, J., Jeziorkowska, R., Vitamin D effects in atopic dermatitis (2013) J Am Acad Dermatol, 69, pp. 238-244
  • Holick, M.F., Vitamin D deficiency (2007) N Engl J Med, 357, pp. 266-281
  • Leekha, S., Diekema, D.J., Perencevich, E.N., Seasonality of staphylococcal infections (2012) Clin Microbiol Infect, 18, pp. 927-933
  • Ogawa, T., Katsuoka, K., Kawano, K., Comparative study of staphylococcal flora on the skin surface of atopic dermatitis patients and healthy subjects (1994) J Dermatol, 21, pp. 453-460
  • Elegbe, I.A., Influence of seasonal and weather variation on the incidence of coagulase positive staphylococci isolates among Nigerians with boil infections (1983) J R Soc Health, 103, pp. 118-119