High-affinity glucose transport in Aspergillus nidulans is mediated by the products of two related but differentially expressed genes

Autor: Forment J.V.; Flipphi M.; Ventura L.; González García, Ramón; Ramon D.; MacCabe A.P.; 

Tipo de documento: Artículo de revista

Revista: PLoS ONE. ISSN: 1932-6203. Año: 2014. Número: 4. Volumen: 9.

Texto completo open access 

Science  Área: MULTIDISCIPLINARY SCIENCES  Quartil: Q1  Lugar área: 08/56  F. impacto: 3,234 

1,3  SNIP: 1,034 



  • Keller, N.P., Turner, G., Bennett, J.W., Fungal secondary metabolism - From biochemistry to genomics (2005) Nature Reviews Microbiology, 3 (12), pp. 937-947. , DOI 10.1038/nrmicro1286, PII N1286
  • Pao, S.S., Paulsen, I.T., Saier Jr., M.H., Major facilitator superfamily (1998) Microbiology and Molecular Biology Reviews, 62 (1), pp. 1-34
  • Ozcan, S., Johnston, M., Function and regulation of yeast hexose transporters (1999) Microbiology and Molecular Biology Reviews, 63 (3), pp. 554-569
  • Leandro, M.J., Fonseca, C., Goncalves, P., Hexose and pentose transport in ascomycetous yeasts: An overview (2009) FEMS Yeast Res, 9, pp. 511-525
  • Palma, M., Goffeau, A., Spencer-Martins, I., Baret, P.V., A phylogenetic analysis of the sugar porters in hemiascomycetous yeasts (2007) Journal of Molecular Microbiology and Biotechnology, 12 (3-4), pp. 241-248. , DOI 10.1159/000099645
  • Wortman, J.R., Gilsenan, J.M., Joardar, V., Deegan, J., Clutterbuck, J., The 2008 update of the Aspergillus nidulans genome annotation: A community effort (2009) Fungal Genet Biol, 46 (SUPPL. 1), pp. S2-S13
  • Gajewski, W., Litwinska, J., Paszewski, A., Chojnacki, T., Isolation and characterization of lactose non-utilizing mutants in Aspergillus nidulans (1972) Mol Gene Genet, 116, pp. 99-106
  • Fantes, P.A., Roberts, C.F., Beta-galactosidase activity and lactose utilization in Aspergillus nidulans (1973) J Gen Microbiol, 77, pp. 417-486
  • Elorza, M.V., Arst Jr., H.N., Sorbose resistant mutants of Aspergillus nidulans (1971) Mol Gen Genet, 111, pp. 185-193
  • Mark, C.G., Romano, A.H., Properties of the hexose transport systems of Aspergillus nidulans (1971) Biochim Biophys Acta, 249, pp. 216-226
  • Schneider, R.P., Wiley, W.R., Kinetic characteristics of the two glucose transport systems in Neurospora crassa (1971) J Bacteriol, 106, pp. 479-486
  • Schulte, T.H., Scarborough, G.A., Characterization of the glucose transport systems in Neurospora crassa sl (1975) J Bacteriol, 122, pp. 1076-1080
  • Rand, J.B., Tatum, E.L., Characterization and regulation of galactose transport in Neurospora crassa (1980) Journal of Bacteriology, 141 (2), pp. 707-714
  • Rand, J.B., Tatum, E.L., Fructose transport in Neurospora crassa (1980) Journal of Bacteriology, 142 (3), pp. 763-767
  • MacCabe, A.P., Miro, P., Ventura, L., Ramon, D., Glucose uptake in germinating Aspergillus nidulans conidia: Involvement of the creA and sorA genes (2003) Microbiology, 149 (8), pp. 2129-2136
  • Forment, J.V., Flipphi, M., Ramon, D., Ventura, L., MacCabe, A.P., Identification of the mstE gene encoding a glucose-inducible, low affinity glucose transporter in Aspergillus nidulans (2006) Journal of Biological Chemistry, 281 (13), pp. 8339-8346. , http://www.jbc.org/cgi/reprint/281/13/8339, DOI 10.1074/jbc.M508198200
  • Wei, H., Vienken, K., Weber, R., Bunting, S., Requena, N., Fischer, R., A putative high affinity hexose transporter, hxtA, of Aspergillus nidulans is induced in vegetative hyphae upon starvation and in ascogenous hyphae during cleistothecium formation (2004) Fungal Genetics and Biology, 41 (2), pp. 148-156. , DOI 10.1016/j.fgb.2003.10.006
  • Clutterbuck, A.J., Aspergillus nidulans (1974) Handbook of Genetics, 1, pp. 447-510. , King RC, editor. New York: Plenum Press
  • Tilburn, J., Scazzocchio, C., Taylor, G.G., Transformation by integration in Aspergillus nidulans (1983) Gene, 26 (2-3), pp. 205-221
  • Flipphi, M., Van De, V.P.J.I., Ruijter, G.J.G., Visser, J., Arst Jr., H.N., Felenbok, B., Onset of carbon catabolite repression in Aspergillus nidulans: Parallel involvement of hexokinase and glucokinase in sugar signaling (2003) Journal of Biological Chemistry, 278 (14), pp. 11849-11857. , DOI 10.1074/jbc.M209443200
  • Oakley, C.E., Weil, C.F., Kretz, P.L., Oakley, B.R., Cloning of the riboB locus of Aspergillus nidulans (1987) Gene, 53 (2-3), pp. 293-298. , DOI 10.1016/0378-1119(87)90019-9
  • Buxton, F.P., Radford, A., Cloning of the structural gene for orotidine 5'-phosphate decarboxylase of Neurospora crassa by expression in Escherichia coli (1983) Molecular and General Genetics, 190 (3), pp. 403-405. , DOI 10.1007/BF00331067
  • Yu, J.-H., Hamari, Z., Han, K.-H., Seo, J.-A., Reyes-Dominguez, Y., Scazzocchio, C., Double-joint PCR: A PCR-based molecular tool for gene manipulations in filamentous fungi (2004) Fungal Genetics and Biology, 41 (11), pp. 973-981. , DOI 10.1016/j.fgb.2004.08.001, PII S1087184504001185
  • Oestreicher, N., Sealy-Lewis, H.M., Scazzocchio, C., Characterisation, cloning and integrative properties of the gene encoding urate oxidase in Aspergillus nidulans (1993) Gene, 132, pp. 185-192
  • Edgar, R.C., MUSCLE: Multiple sequence alignment with high accuracy and high throughput (2004) Nucleic Acids Res, 32, pp. 1792-1797
  • Edgar, R.C., MUSCLE: A multiple sequence alignment method with reduced time and space complexity (2004) BMC Bioinformatics, 5, pp. 113-131
  • Abascal, F., Zardoya, R., Posada, D., ProtTest: Selection of best-fit models of protein evolution (2005) Bioinformatics, 21 (9), pp. 2104-2105. , DOI 10.1093/bioinformatics/bti263
  • Darriba, D., Toboada, G.L., Doallo, R., Posada, D., ProtTest 3: Fast selection of best-fit models of protein evolution (2011) Bioinformatics, 27, pp. 1164-1165
  • Guindon, S., Dufayard, J.F., Lefort, V., Anisimova, M., Hordijk, W., Gascuel, O., New Algorithms and Methods to Estimate Maximum-Likelihood Phylogenies: Assessing the Performance of PhyML 3.0 (2010) Systematic Biology, 59, pp. 307-321
  • Tamura, K., Peterson, D., Peterson, N., Stecher, G., Nei, M., Kumar, S., MEGA5: Molecular Evolutionary Genetics Analysis using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods (2011) Mol Biol Evol, 28, pp. 2731-2739
  • Krogh, A., Larsson, B., Von Heijne, G., Sonnhammer, E.L.L., Predicting transmembrane protein topology with a hidden Markov model: Application to complete genomes (2001) Journal of Molecular Biology, 305 (3), pp. 567-580. , DOI 10.1006/jmbi.2000.4315
  • Galagan, J.E., Calvo, S.E., Cuomo, C., Ma, L.-J., Wortman, J.R., Batzoglou, S., Lee, S.-I., Birren, B.W., Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae (2005) Nature, 438 (7071), pp. 1105-1115. , DOI 10.1038/nature04341
  • Payne, G.A., Nierman, W.C., Wortman, J.R., Pritchard, B.L., Brown, D., Whole genome comparison of Aspergillus flavus and A. oryzae (2006) Med Mycol, 44, pp. S9-S11
  • Clutterbuck, A.J., The validity of the Aspergillus nidulans linkage map (1997) Fungal Genet Biol, 21, pp. 267-277
  • Leatherbarrow, R.J., Using linear and non-linear regression to fit biochemical data (1990) Trends Biochem Sci, 15, pp. 455-458
  • Fuhrmann, G.F., Volker, B., Misuse of graphical analysis in nonlinear sugar transport kinetics by Eadie-Hofstee plots (1993) Biochimica et Biophysica Acta - Biomembranes, 1145 (1), pp. 180-182. , DOI 10.1016/0005-2736(93)90396-H
  • Heytler, P.G., Uncouplers of oxidative phosphorylation (1979) Methods Enzymol, 55, pp. 462-472
  • Arst Jr., H.N., Cove, D.J., Nitrogen metabolite repression in Aspergillus nidulans (1973) Mol Gen Genet, 126, pp. 111-141
  • Herrin, D.L., Schmidt, G.W., Rapid reversible staining of northern blots prior to hybridization (1988) Biotechniques, 6, pp. 196-200
  • D'Enfert, C., Fungal spore germination: Insights from the molecular genetics of Aspergillus nidulans and Neurospora crassa (1997) Fungal Genet Biol, 21, pp. 163-172
  • Tatum, E.L., Barratt, R.W., Cutter Jr., V.M., Chemical induction of colonial paramorphs in Neurospora and Syncephalastrum (1949) Science, 109, pp. 509-511
  • Klingmuller, W., Huh, H., Kaudewitz, F., Regulatory function of sorbose-resistance gene C in sugar transport of Neurospora (1970) Mol Gen Genet, 109, pp. 27-41
  • Scarborough, G.A., Sugar transport in Neurospora crassa. II A second glucose transport system (1970) J Biol Chem, 245, pp. 3985-3987
  • Schneider, R.P., Wiley, W.R., Regulation of sugar transport in Neurospora crassa (1971) J Bacteriol, 106, pp. 487-492
  • Cubero, B., Scazzocchio, C., Two different, adjacent and divergent zinc finger binding sites are necessary for CREA-mediated carbon catabolite repression in the proline gene cluster of Aspergillus nidulans (1994) EMBO Journal, 13 (2), pp. 407-415
  • Panozzo, C., Cornillot, E., Felenbok, B., The CreA repressor is the sole DNA-binding protein responsible for carbon catabolite repression of the alcA gene in Aspergillus nidulans via its binding to a couple of specific sites (1998) Journal of Biological Chemistry, 273 (11), pp. 6367-6372. , DOI 10.1074/jbc.273.11.6367
  • Mathieu, M., Fillinger, S., Felenbok, B., In vivo studies of upstream regulatory cis-acting elements of the alcR gene encoding the transactivator of the ethanol regulon in Aspergillus nidulans (2000) Molecular Microbiology, 36 (1), pp. 123-131. , DOI 10.1046/j.1365-2958.2000.01833.x
  • Orejas, M., MacCabe, A.P., Perez, G.J.A., Kumar, S., Ramon, D., Carbon catabolite repression of the Aspergillus nidulans xlnA gene (1999) Molecular Microbiology, 31 (1), pp. 177-184. , DOI 10.1046/j.1365-2958.1999.01157.x
  • Garcia, J.C., Strube, M., Leingang, K., Keller, K., Mueckler, M.M., Amino acid substitutions at tryptophan 388 and tryptophan 412 of the HepG2 (Glut1) glucose transporter inhibit transport activity and targeting to the plasma membrane in Xenopus oocytes (1992) J Biol Chem, 267, pp. 7770-7776
  • Dos Reis, T.F., Menino, J.F., Bom, V.L., Brown, N.A., Colabardini, A.C., Identification of glucose transporters in Aspergillus nidulans (2013) PLoS One, 8, pp. e81412
  • VanKuyk, P.A., Diderich, J.A., MacCabe, A.P., Hererro, O., Ruijter, G.J.G., Visser, J., Aspergillus niger mstA encodes a high-affinity sugar/H+ symporter which is regulated in response to extracellular pH (2004) Biochemical Journal, 379 (2), pp. 375-383. , DOI 10.1042/BJ20030624