Genetic characterization of the mechanisms of resistance to amoxicillin/clavulanate and third-generation cephalosporins in Salmonella enterica from three Spanish hospitals

Autor: Toro Hernando, María deSáenz Domínguez, María Yolanda; Cercenado, Emilia; Rojo Bezares, Beatriz; García-Campello, M.; Undabeitia, E.; Torres Manrique, Carmen

Tipo de documento: Artículo de revista

Revista: International Microbiology. ISSN: 1139-6709. Año: 2011. Número: 3. Volumen: 14. Páginas: 173-181.

doi 10.2436/20.1501.01.146Texto completo open access 

Science  Área: BIOTECHNOLOGY & APPLIED MICROBIOLOGY  Quartil: Q3  Lugar área: 108/158  F. impacto: 1,407 
Science  Área: MICROBIOLOGY  Quartil: Q3  Lugar área: 84/113  F. impacto: 1,407 

,869  SNIP: ,986 



  • Antunes, P., Machado, J., Peixe, L., Dissemination of sul3-containing elements linked to class 1 integrons with an unusual 3′ conserved sequence region among Salmonella isolates (2007) Antimicrob Agents Chemother, 51, pp. 1545-1548
  • Arlet, G., Barrett, T.J., Butaye, P., Cloeckaert, A., Mulvey, M.R., White, D.G., Salmonella resistant to extended-spectrum cephalosporins: Prevalence and epidemiology (2006) Microbes Infect, 8, pp. 1945-1954
  • Biendo, M., Laurans, G., Thomas, D., Canarelli, B., Hamdad-Daoudi, F., Rousseau, F., Castelain, S., Eb, F., Molecular characterisation and mechanisms of resistance of multidrug-resistant human Salmonella enterica serovar Typhimurium isolated in Amiens (France) (2005) Int J Antimicrob Agents, 26, pp. 219-229
  • Cambray, G., Guerout, A.M., Mazel, D., (2010) Integrons. Annu Rev Genet, 44, pp. 141-166
  • (2010) Performance Standards For Antimicrobial Susceptibility Testing: Eighteenth Informational Supplement M100-S20, , Clinical and Laboratory Standards Institute, CLSI, Wayne, PA, USA
  • Coque, T.M., Baquero, F., Canton, R., Increasing prevalence of ESBL-producing Enterobacteriaceae in Europe (2008) Euro Surveill, 13, p. 19044
  • de Toro, M., Rojo-Bezares, B., Vinue, L., Undabeitia, E., Torres, C., Saenz, Y., In vivo selection of a aac(6′)-Ib-cr and mutations in the gyrA gene in a clinical qnrS1-positive Salmonella enterica serovar Typhimurium DT104B strain recovered after fluoroquinolone treatment (2010) J Antimicrob Chemother, 65, pp. 1945-1949
  • The Community summary report on trends and sources of zoonoses and zoonotic agents in the European Union in 2007 (2009) EFSA J, p. 223. , European Food Safety Authority (EFSA)
  • Gonzalez-Sanz, R., Herrera-Leon, S., de la Fuente, M., Arroyo, M., Echeita, M.A., Emergence of extended-spectrum β-lactamases and AmpCtype β-lactamases in human Salmonella isolated in Spain from 2001 to 2005 (2009) J Antimicrob Chemother, 64, pp. 1181-1186
  • Guerra, B., Soto, S., Helmuth, R., Mendoza, M.C., Characterization of a self-transferable plasmid from Salmonella enterica serotype Typhimurium clinical isolates carrying two integron-borne gene cassettes together with virulence and drug resistance genes (2002) Antimicrob Agents Chemother, 46, pp. 2977-2981
  • Guerri, M.L., Aladuena, A., Echeita, A., Rotger, R., Detection of integrons and antibiotic-resistance genes in Salmonella enterica serovar Typhimurium isolates with resistance to ampicillin and variable susceptibility to amoxicillin-clavulanate (2004) Int J Antimicrob Agents, 24, pp. 327-333
  • Herrero, A., Mendoza, M.C., Threlfall, E.J., Rodicio, M.R., Detection of Salmonella enterica serovar Typhimurium with pUO-StVR2-like virulence- resistance hybrid plasmids in the United Kingdom (2009) Eur J Clin Microbiol Infect Dis, 28, pp. 1087-1093
  • Jarlier, V., Nicolas, M.H., Fournier, G., Philippon, A., Extended broadspectrum β-lactamases conferring transferable resistance to newer β-lactam agents in Enterobacteriaceae: Hospital prevalence and susceptibility patterns (1988) Rev Infect Dis, 10, pp. 867-878
  • Michael, G.B., Butaye, P., Cloeckaert, A., Schwarz, S., Genes and mutations conferring antimicrobial resistance in Salmonella: An update (2006) Microbes Infect, 8, pp. 1898-1914
  • Miriagou, V., Tassios, P.T., Legakis, N.J., Tzouvelekis, L.S., Expandedspectrum cephalosporin resistance in non-typhoid Salmonella (2004) Int J Antimicrob Agents, 23, pp. 547-555
  • Mulvey, M.R., Boyd, D.A., Olson, A.B., Doublet, B., Cloeckaert, A., The genetics of Salmonella genomic island 1 (2006) Microbes Infect, 8, pp. 1915-1922
  • Oliver, A., Coque, T.M., Alonso, D., Valverde, A., Baquero, F., Canton, R., CTX-M-10 linked to a phage-related element is widely disseminated among Enterobacteriaceae in a Spanish hospital (2005) Antimicrob Agents Chemother, 49, pp. 1567-1571
  • Pardos de la Gandara, M., Seral, C., Castillo, G.J., Rubio, C.C., Weill, F.X., Prevalence and characterization of extended-spectrum beta-lactamases-producing Salmonella enterica isolates in Saragossa, Spain (2001-2008) (2011) Microb Drug Resist, 17, pp. 207-213
  • Partridge, S.R., Analysis of antibiotic resistance regions in Gramnegative bacteria (2011) FEMS Microbiol Rev, 35, pp. 820-855
  • Perez-Perez, F.J., Hanson, N.D., Detection of plasmid-mediated AmpC β-lactamase genes in clinical isolates by using multiplex PCR (2002) J Clin Microbiol, 40, pp. 2153-2162
  • Riano, I., Garcia-Campello, M., Saenz, Y., Alvarez, P., Vinue, L., Lantero, M., Moreno, M.A., Torres, C., Occurrence of extendedspectrum β-lactamase-producing Salmonella enterica in northern Spain with evidence of CTX-M-9 clonal spread among animals and humans (2009) Clin Microbiol Infect, 15, pp. 292-295
  • Rodriguez, I., Guerra, B., Mendoza, M.C., Rodicio, M.R., pUO-SeVR1 is an emergent virulence-resistance complex plasmid of Salmonella enterica serovar Enteritidis (2011) J Antimicrob Chemother, 66, pp. 218-220
  • Romero, L., Lopez, L., Martinez-Martinez, L., Guerra, B., Hernandez, J.R., Pascual, A., Characterization of the first CTX-M-14-producing Salmonella enterica serotype Enteritidis isolate (2004) J Antimicrob Chemother, 53, pp. 1113-1114
  • Saenz, Y., Brinas, L., Dominguez, E., Ruiz, J., Zarazaga, M., Vila, J., Torres, C., Mechanisms of resistance in multiple-antibiotic-resistant Escherichia coli strains of human, animal, and food origins (2004) Antimicrob Agents Chemother, 48, pp. 3996-4001
  • Sáenz, Y., Vinué, L., Ruiz, E., Somalo, S., Martínez, S., Rojo-Bezares, B., Zarazaga, M., Torres, C., Class 1 integrons lacking qacEDelta1 and sul1 genes in Escherichia coli isolates of food, animal and human origins (2010) Vet Microbiol, 144, pp. 493-497
  • Soto, S.M., Gonzalez-Hevia, M.A., Mendoza, M.C., Antimicrobial resistance in clinical isolates of Salmonella enterica serotype Enteritidis: Relationships between mutations conferring quinolone resistance, integrons, plasmids and genetic types (2003) J Antimicrob Chemother, 51, pp. 1287-1291
  • Sunde, M., Norstrom, M., The prevalence of, associations between and conjugal transfer of antibiotic resistance genes in Escherichia coli isolated from Norwegian meat and meat products (2006) J Antimicrob Chemother, 58, pp. 741-747
  • Sutcliffe, J.G., Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322 (1978) Proc Natl Acad Sci USA, 75, pp. 3737-3741
  • Tan, T.Y., Ng, L.S., He, J., Koh, T.H., Hsu, L.Y., Evaluation of screening methods to detect plasmid-mediated AmpC in Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis (2009) Antimicrob Agents Chemother, 53, pp. 146-149
  • Targant, H., Ponsin, C., Brunet, C., Doublet, B., Cloeckaert, A., Madec, J.Y., Meunier, D., Characterization of resistance genes in multidrugresistant Salmonella enterica serotype Typhimurium isolated from diseased cattle in France (2002 to 2007) (2010) Foodborne Pathog Dis, 7, pp. 419-425
  • Vinue, L., Lantero, M., Saenz, Y., Somalo, S., de Diego, I., Perez, F., Ruiz-Larrea, F., Torres, C., Characterization of extendedspectrum β-lactamases and integrons in Escherichia coli isolates in a Spanish hospital (2008) J Med Microbiol, 57, pp. 916-920
  • Vinué, L., Sáenz, Y., Rojo-Bezares, B., Olarte, I., Undabeitia, E., Somalo, S., Zarazaga, M., Torres, C., Genetic environment of sul genes and characterisation of integrons in Escherichia coli isolates of blood origin in a Spanish hospital (2010) Int J Antimicrob Agents, 35, pp. 492-496